Celebrex is an inhibiting selective one COX-2 (read the Inhibiting original article COX-1 vs. COX-2) and is one of the most recent groups of the anti-inflammatory medicines not esteroideo available in the market. It was approved for its utilization in the processing of osteoporosis and arthritis reumatoide in dose of an and of two times al day. It was not approved by the FDA for the relief of pain by itself, as is the postoperative pain. This medicine has a smaller incident of gastric ulcers associates al to compare it with the anti-inflammatory medicines not esteroideos traditional that inhibit so much the ciclooxigenasa 1 as the ciclooxigenasa 2. Celebrex does not interfere with the platelets because the platelets do not contain ciclooxigenasa-2. This medicine does not promote bruises or bled with facility as happens with the medicines not esteroideos traditional. The patients that require of effects antiplaquetas for the prevention of attacks al heart, they should administer them a low dose of aspirin as a group with the Celebrex, to generate this effect.
Due to that this medicine does not promote bled gastrointestinal, is surer than the anti-inflammatorys not esteroideos, when is utilized as a group with Coumadin (warfarina). It is important to maintain a monitoring of time of protrombina to be assured that Celebrex is not affecting adversly the quantity desired of anticoagulant in the blood.
Celebrex has part of the group of sulfonamida in the molecule. It is prudent that the patients that have a true record of allergy to the antibiotics with sulfonamida, they avoid the use of Celebrex, in order to avoiding an allergic reaction. Celebrex can interact with the kidneys. Therefore, it is important that the patients that have renal dysfunction, they maintain a blood tests monitoring, included nitrogen ureico in blood (NUS) and creatinina sérica to be assured that Celebrex is not contributing al deterioration of the renal function.
Celebrex is an excellent medicine to add al armamentario of anti-inflammatorys not esteroideos. It is of most greatest benefit for patient with antecedents of gastrointestinal problems that do not tolerate the anti-inflammatory medicines not esteroideos traditional. Now the patients have an alternative medicine that has a marked reduction of incident of ulceración gastrointestinal and bled.
